Pharmacology NCLEX Questions | Free Practice Exam

Pharmacology makes up about 12–15% of NCLEX-RN and NCLEX-PN questions. You will be tested on how medications work, recognizing therapeutic and adverse effects, calculating and administering safe dosages, monitoring for drug interactions and contraindications, educating patients about their medications, and responding appropriately to emergencies or adverse reactions.

NCLEX Pharmacology Questions

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Question 1

A client taking warfarin for atrial fibrillation is prescribed trimethoprim-sulfamethoxazole for a UTI. What is the nurse’s priority concern?

A
Decreased warfarin effectiveness
B
Risk for hypoglycemia
C
Increased bleeding risk
D
Kidney failure
Question 1 Explanation: 
TMP-SMX increases warfarin levels → elevated INR → hemorrhage risk.
Question 2
A client with heart failure is taking digoxin and furosemide. Which finding requires immediate action?
A
Apical pulse 58 bpm
B
Urine output 1500 mL/day
C
BP 110/70
D
Potassium 3.0 mEq/L
Question 2 Explanation: 
Low K⁺ increases digoxin toxicity risk → fatal arrhythmias.
Question 3

A client receiving morphine IV becomes difficult to arouse. Respirations are 7/min.

Which medication should the nurse prepare?

A
Flumazenil
B
Atropine
C
Epinephrine
D
Naloxone
Question 3 Explanation: 
Opioid overdose → respiratory depression → opioid antagonist needed.
Question 4

A client taking lisinopril develops facial swelling and difficulty breathing.

What is the nurse’s priority action?

A
Administer antihistamine
B
Give IV fluids
C
Check blood pressure
D
Stop the medication and call rapid response
Question 4 Explanation: 
ACE inhibitor–induced angioedema → airway emergency.
Question 5

A client taking metformin is scheduled for a CT scan with contrast dye.

What should the nurse do?

A
Give the medication with food
B
Hold the medication before the procedure
C
Encourage fluids only
D
Administer insulin instead
Question 5 Explanation: 
Contrast + metformin → lactic acidosis risk if kidneys are affected.
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